Abstract: Plywoods were fabricated using inner-layer veneers and outer-layer veneers through diverse lamination configurations and number of plies. Modulus of elasticity (MOE), modulus of rupture (MOR), bonding strength, and immersion delamination resistance were employed as evaluation indices to quantify the physico-mechanical properties. The results showed that bending performance positively correlated with vascular bundle content, exhibiting the order: outer-layer plywood (Q-plywood) > mixed-lamination plywood (B-plywood) > inner-layer plywood( H-plywood). Bonding strength increased with the number of plies in the laminated panel, showing 133.5%, 253.6%, and 168.1% enhancements for Q, B, and H-plywoods, respectively, from 3-ply to 9-ply. Conversely, bonding strength negatively correlated with veneer wettability (Q > B/H). Immersion delamination resistance improved with the number of plies in the laminated panel but (plywoods with different lamination configurations) was influenced by thickness swelling anisotropy. Optimized lamination structures enhance targeted performance advantages of flattened bamboo plywood. This study offers technical support for developing cost-effective products tailored to diverse application scenarios.