Abstract: Based on climate data of three stations (Zoige, hongyuan, maqu) of Zoige plateau from 1967 to 2014. Application of linear regression calculation of annual and seasonal climatic change trend, and MannKendall method of three stations data of climate change for mutation analysis. The results show that the climate change in Zoige plateau is: the rise of the temperature, the decrease of precipitation and evaporation quantity, climate was warm and dry in the direction of the trend. Seasonal temperature showed an upward trend, and the trend is evident in winter. In addition to the autumn precipitation reduced obviously, the rest of the season showed a slight upward trend, the general tendency of precipitation is decrease. Seasonal evapotranspiration showed a rising trend, and the trend reached the maximum in autumn. Air temperature had a mutation in 1997. Since then, the upward trend is obvious. Two mutations of precipitation occurred in 1975 and 1985, respectively. Precipitation increased slowly after the second mutation and began to decrease in 1991. Evaporation quantity had two mutations in 1994 and 1999, respectively.