Abstract: In this paper, the typical Minqin oasis were taken as research area.Based on GF-1 images as data sources, and using vegetation coverage estimation model, the vegetation coverage from 2013 to 2015 were estimated and classified, the spatio-temporal variation rules of different vegetation coverage were quantitative studied.Analysis showed that the vegetation coverage of Minqin Oasis remained stable during the 3 study years and that of the extremely low covered vegetation, called Class Ⅰ, increased from 76.9% in 2013 to 83.9% in 2015.Low covered vegetation that called Class Ⅱ and high covered vegetation that was defined as Class Ⅳ was respectively reduced by 6.8% and 1.9%.The intermediate covered vegetation, named Class Ⅲ increased by 1.7%.In a whole, under the premise of the overall stability of vegetation coverage, due to the serious impact of human activities, a few parts of wild black Chinese wolfberry and other rare medicinal herbs growing areas′ vegetation coverage were decreased significantly.