Abstract: Based on the remote sensing image data from 1998 to 2018, the method of combining supervised classification and visual correction is used to interpret the remote sensing image, and the landscape area transfer matrix and moving landscape grid index are constructed to analyze the landscape pattern change characteristics of Zunyi downtown. The results show that from 1998 to 2018, the farmland in the central urban area of Zunyi was mainly converted into road traffic, urban and rural residents and industrial mines, while the forest land was mainly converted into farmland, urban park green space, urban and rural residents and industrial mines; the overall landscape fragmentation degree of the study area continued to increase, the shape of the patches became more and more simple, the land use became more and more diversified, and the information content of the uncertainty was also larger, and the patches gradually presents the spatial characteristics of uniform distribution. Population growth, economic growth, industrial development and industrial structure adjustment are the main driving forces of landscape pattern evolution in Zunyi downtown. This study can provide a reference for the land development and spatial development strategy in the central district of Zunyi City.