Abstract: Using bamboo mats, thick (thin) bamboo curtains and poplar veneers as materials, after applying phenolic resin glue, according to the principles of symmetry, odd numbers and thickness, the layers are crisscrossed to form blanks, which are prepared by hot pressing into high performance bamboo-based heat-curing composite board. The product was optimized by response surface method design and data analysis. The results show that the best process conditions are hot pressing temperature of 140 ℃, hot pressing time of 92 s/mm, and hot pressing pressure of 2.5 MPa. The model was verified according to the optimal process parameters. The product had an elastic modulus of 8.74 GPa, a static bending strength of 98.2 MPa, a water absorption thickness expansion rate of 4.8%, a gluing strength of 0.91 MPa, and a density of 0.89 g/cm³. The actual value is close to the predicted value, confirming that the obtained model can accurately predict the MOE of the product using the 3 factors of hot pressing as variables under different conditions.