Abstract: Based on the MODIS data of GEE platform, the ecological environment quality of Yunnan from 2000 to 2020 was calculated and its evolution process was analyzed; the GWR model was used to analyze the impact of natural and social economy on the ecological environment, and we also looked into the factors that drive changes in environmental quality in Yunnan. The results show that the overall ecological environment quality of Yunnan has been steadily increasing, and the spatial distribution pattern is high in the west and low in the east; 2010 is a typical year, affected by extreme drought, the overall quality of the ecological environment declined. From 2000 to 2020, the global Morant index of ecological environment quality was greater than 0.7, and the spatial heterogeneity of ecological environment quality in Yunnan was large, mainly in alpine mountainous areas and rocky desertification areas. The northwestern Yunnan region showed high-value clustering, and the rocky desertification area in eastern Yunnan showed low-value clustering. The quality of ecological environment is positively correlated with precipitation, negatively correlated with human activities, and polarized with temperature, altitude, GDP and urbanization. The ecological environment quality of Yunnan is complex. We should pay attention to the stability of the ecosystem in the alpine region of northwest Yunnan and the control of rocky desertification in eastern Yunnan, protect the ecological environment and reduce the damage of human activities to the ecological environment.