Abstract: Taking the medium size indicator mammal Chinese river deer (Hydropotes inermis) in eastern suburb of Nanjing City as the research object, and 47 species evidence data collected between 2007-2009 together with data of 8 environmental variables provided by basic geographic information database of Jiangsu Province as the major information source, a potential habitat forecast model was established by means of the maximum entropy method (Maxent) under the support of spatial information technology of Geomatics. Then the landscape security pattern of Hydropotes inermis was built through spatial analysis module of ArcGIS. The results showed that the potential habitat of the protected wild animal was highly fragmented under the influence of bird cage effect from the rapid transportation network. Among the 8 environmental factors that influenced on the potential habitat for Hydropotes inermis, the contribution ratio of the distance to highway (41.9%), distance to railroad (17.8%) and the distance to residence (14.7%) accounted for 74.4%. Inside the study area, there were 3 patches of potential habitats for the animal which comprised continentisland comprehensive population pattern, 4 pieces of inter-source linkage corridors, 3 patches of strategic points situated in the valley and saddle localities.