Abstract: The response surface methodology (RSM) was adopted to optimize the manufacturing technology of preserved Pinus massoniana plywood by taking phenolic resin as adhesive and taking the blends of boric acid, glyoxal, glycerol and water as preservatives, respectively. The experiments were conducted by applying the weight content of glyoxal in the preservatives, the drying temperature and drying time duration as variables, and by taking the bonding strength (Y1) of the preserved P. massoniana plywood and the retention rate of boron (Y2) as response variables, and then the formulas for Y1 and Y2 were built. The optimum technology parameters for the preserved P. massoniana plywood manufacture were obtained that 2.00% as the weight content of glyoxal in the preservatives, 70 ℃ as the drying temperature,and 5 hrs as the drying time duration. The values of Y1 and Y2 of the plywood manufactured with the optimized technology was 1.42 MPa and 4552% respectively, which were close to the predicted values. The results indicated that the manufacturing technology for preserved P. massoniana plywood optimized by RSM could provide the production with theoretical reference.